Hypercholesterolemia aggravates radiocontrast nephrotoxicity: Protective role of L-arginine
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چکیده
منابع مشابه
The possible protective effect of L-arginine against 5-fluorouracil-induced nephrotoxicity in male albino rats.
5-fluorouracil (5-FU) is a potent antineoplastic agent used for the treatment of various malignancies. The L-argininenitric oxide (NO) pathway involved in the pathogenesis of chemotherapy induced kidney damage. This work investigated the beneficial mechanism of L-arginine supplementation in 5 FU induced nephropathy. Eighty male Wistar rats were divided into four equal groups: Control group; L-a...
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BACKGROUND Cisplatin (CP) is accompanied with a nephrotoxicity. L-arginine (LA) plays an important role in the regulation of renal function. The present study was designed to investigate the protective role of LA supplementation in CP-induced nephrotoxicity in a diabetic rat's model. MATERIALS AND METHODS Sixteen adult female and male Wistar rats were used and they received a single dose of s...
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Effects of L-arginine (L-arg) and aminoguanidine (AG) on the nephrotoxicity induced by cyclosporine (CsA) were investigated. After injection of CsA (15 mg kg(-1) day (-1)i.p. for 10 days), it induced nephrotoxicity, manifested biochemically by a significant elevation of serum urea and creatinine. In addition, a marked increase in lipid peroxides measured as malondialdehyde (MDA) as well as a si...
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BACKGROUND Cisplatin (CP) as a potential drug for solid tumors produces nephrotoxicity and disturbs endothelial function. CP induced nephrotoxicity may be gender related. Nitric oxide plays a pivotal role in endothelial function and L-arginine as endogenous NO donor promotes endothelial function. The role of L-arginine in CP induced nephrotoxicity model and its gender related was investigated i...
متن کاملprotective effects of l-arginine (precursor of no) oniron-induced nephrotoxicity in rats
introduction: iron overload has been implicated as an important factor for nephropathy by hydroxyl radicals production. on the other hand nitric oxide (no) asa reactive free radical, has numerous effects on kidney. however at high concentration it has been suggested to have toxic effects. in this study the interaction between iron overload and no system on renal function were evaluated in rats....
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ژورنال
عنوان ژورنال: Kidney International
سال: 1998
ISSN: 0085-2538
DOI: 10.1046/j.1523-1755.1998.00906.x